In this course, we will review recent randomized controlled trials investigating the efficacy of endovascular thrombectomy (EVT) for two populations – the large core and medium vessel occlusion subgroups. We will focus on the role that neuroimaging plays as a central focus in these trials, particularly in regard to eligibility criteria. Additionally, we will critique the trials and discuss future directions with respect to the role of neuroimaging in setting up future trials.

	Achala Vagal, MD, MS, FAHA University of Cincinnati Dr. Achala Vagal is Tenured Professor of Radiology and is Executive Vice Chair and Vice Chair of Research in Department of Radiology at University of Cincinnati (UC). She is also the Associate Dean of Clinical and Translational Research at UC College of Medicine and Co-Director of the NCATS funded Center for Clinical and Translational Science and Training. Dr. Vagal has expertise in neuroimaging of cerebrovascular diseases with extensive experience in leading imaging core labs for large, multicenter trials.
	Vivek Yedavalli, MD, MS Johns Hopkins University School of Medicine Dr. Vivek Srikar Yedavalli is an Associate Professor of Radiology and Radiological Science, Associate Professor of Neurology, the Director of Stroke, Neurovascular, and Perfusion Imaging at Johns Hopkins Hospital, Chief of Neuroradiology at Johns Hopkins Bayview Medical Center, and Assistant Director of the Department of Radiology Physician Scientist Incubator Program. Dr. Yedavalli has been recognized nationally as a translational stroke and perfusion imaging researcher and physician-scientist. Within one year of his appointment at Johns Hopkins, Dr. Yedavalli received the Radiological Society of North America (RSNA)’s Seed Grant using MRI spectroscopy for prognostication in subacute ischemic stroke. Dr. Yedavalli was then chosen as the inaugural recipient of the Johns Hopkins University Department of Radiology Physician Scientist Incubator Program (RAD-PSI), an internal grant that also confers funding and protected time for his stroke work. The following year, for applying his work on collateralization based on CT perfusion within acute ischemic stroke with artificial intelligence, Dr. Yedavalli was awarded the RSNA Scholar Grant. He was previously the recipient of the Department of Radiology Education Award during his residency training. He prefers a balanced teaching approach with trainees with focused learning while maintaining autonomy for a more productive learning environment.
	Gustavo A. Mendez, MD University of Colorado School of Medicine Dr. Gustavo Mendez is an Assistant Professor in Neuroradiology at the University of Colorado School of Medicine. Dr. Mendez has a clinical and research focus in stroke and neurovascular imaging, leading stroke educational and multidisciplinary conferences at the University of Colorado. He completed his diagnostic radiology residency at the University of Chicago and his neuroradiology fellowship at Stanford University.

In this course, we will review recent randomized controlled trials investigating the efficacy of endovascular thrombectomy (EVT) for two populations – the large core and medium vessel occlusion subgroups. We will focus on the role that neuroimaging plays as a central focus in these trials, particularly in regard to eligibility criteria. Additionally, we will critique the trials and discuss future directions with respect to the role of neuroimaging in setting up future trials.

Content Areas (Codes):
The following Content Areas will be printed on the certificate for this course:

• Computed Tomography
• Magnetic Resonance Imaging
• Neuroradiology

Learning Objectives:

• Review neuroimaging criteria used in the five major large core ischemic stroke trials
• Evaluate the role of neuroimaging for eligibility in the three medium vessel stroke trials
• Examine future directions where neuroimaging can be more optimally utilized in future trials

This Other activity (live and enduring material) is estimated to take 1 hour to complete.

Start Date: 6/11/2025
End Date for CME Eligibility/Online Expiration Date: 6/10/2026

This educational activity was originally presented on 6/11/2025 as an interactive online webinar.

Faculty:

• Gustavo A. Mendez, MD

Planners:

• Achala Vagal, MD, MS, FAHA
• Vivek Yedavalli, MD, MS

Disclosure Statements:
RSNA controls the planning, development, and delivery of this CME activity and will strictly adhere to the Standards for Integrity and Independence in Accredited Continuing Education established by the Accreditation Council for Continuing Medical Education (ACCME).

Listed below are all the financial disclosures provided by individuals in a position to influence and/or control CME activity content. All the financial relationships listed for these individuals have been mitigated. Please note that any individuals not listed below have reported no financial relationships (currently or within the past 24 months) with any ineligible company producing, marketing, selling, re-selling, or distributing health care products used on or by patients.

Faculty:

• None of the faculty for this educational activity have relevant relationships with ineligible companies to disclose.

Planners:

• Achala Vagal, MD, MS, FAHA: Consultant, Cerebra AI

Accreditation and Designation Statements:
The Radiological Society of North America (RSNA) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The RSNA designates this Other activity (live and enduring material) for a maximum of 1.00 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

To earn CME credit, participants must watch the full length of the webinar, as well as complete the course evaluation.

Price:
Non-Member/Basic Member Rate: $0.00
Standard Member/Full Access Member Rate: $0.00

Refund / Exchange Policy:
RSNA will not issue any refunds or exchanges for online only versions of educational products or activities purchased online. Please review the entire product or activity description prior to purchase.

RSNA Disclaimer:
The opinions or views expressed in this activity are those of the presenters and do not necessarily reflect the opinions, recommendations or endorsement of the RSNA. Participants should critically appraise the information presented and are encouraged to consult appropriate resources for information surrounding any product or device mentioned. Information presented, as well as publications, technologies, products and/or services discussed, are intended to inform the learner about the knowledge, techniques, and experiences of RSNA faculty who are willing to share such information with colleagues. The RSNA disclaims any and all liability for damages to any individual user for all claims which may result from the use of said information, publications, technologies, products and/or services, and events.