Imaging Gliomas: The Good, Bad and Ugly (2025)-M1-CNR0321-2025

Video Transcription

Video Summary

The video transcript presents an insightful overview of the advancements and current practices in the classification and imaging of gliomas, particularly focusing on the World Health Organization's recent updates and the role of radiologists. It highlights the clear distinction made between adult-type and pediatric-type diffuse gliomas, which acknowledges their inherent differences. The transcript delves into the importance of molecular diagnostics, emphasizing how they have become increasingly pivotal in tumor classification since the 2016 updates. The significance of IDH mutation status, 1p19q co-deletion, and their implications for defining glioblastoma are explored, showcasing the nuanced approach required for accurate diagnosis and classification.<br /><br />The transcript further discusses the challenges presented by pseudoresponse and pseudoprogression phenomena, which complicate the assessment of tumor progression or response to treatment. It underscores the importance of a systematic approach, such as the Response Assessment in Neuro-Oncology (RANO) criteria, which facilitate better clinical decision-making by combining clinical context with advanced imaging techniques, including radiomics and AI-driven analyses. These innovations provide enhanced capabilities in differentiating between tumor recurrence and treatment-related changes, promising a future where personalized medicine and precision diagnostics lead to improved patient outcomes in neuro-oncology.

Keywords

gliomas

World Health Organization

molecular diagnostics

IDH mutation

1p19q co-deletion

pseudoresponse

pseudoprogression

RANO criteria

radiomics